Muscle weakness, fasciculation, fatigue and paralysis Nicotinic overstimulation at the neuromuscular junction causes Stimulation manifesting as tachycardia, hypertension, sweating and rarelyĭilated pupil.

Nicotinic activity results in autonomic nervous system Adrenal medulla activity manifest as increased sweatingĪnd garlic smell because of vicarious excretion, bradycardia, abdominal Membranes, increased pulmonary and oropharnygeal secretions, pupillaryĬonstriction manifesting as diarrhoea, excessive urination, miosis, bronchorrhea,īradycardia, emesis, lacrimation and salivation, commonly tagged with the Muscarinic symptoms include excessive secretion from mucus Symptoms of exposure which typically appear within 30 to 90 minutes after exposures are due to the continuous stimulation of the muscarinic and nicotinic receptors. SIGNS AND SYMPTOMS: Signs and symptoms of OP poisoning can be divided into three broad categories: (1) Muscarinic effects, (2) Nicotinic effects, and (3) Central Nervous System (CNS) effects. To the use of atropine is recommended to minimize the potential for Management must focus on adequate use of atropine. Include atropine, pralidoxime, and benzodiazepines (eg, diazepam). AirwayĬontrol and oxygenation are paramount. TREATMENT: Treatment begins with decontamination. Themselves, the degree of risk appears to be very small. Risk of health care workers taking care of a poisoned person becoming poisoned

Other means, has not been shown to be useful. While there is a theoretical Among those who work with pesticides the use of protectiveĬlothing and showering before going home is also useful.Īs oxygen and intravenous fluids are also recommended.Īttempts to decontaminate the stomach, with activated charcoal or PREVENTION: Prevention efforts include banning every toxic

Antidote for organophosphate poisoning